Is your skincare pregnancy-safe?
Tap your actives or paste a label. See what to avoid, with sources.
- 1Actives
- 2Sorted
- 3Your list
Not medical advice: bring it to your OB-GYN.
Not medical advice: bring it to your OB-GYN.
Three stamps. The cautious one wins.
Avoid while pregnant: an FDA label, the AAD, ACOG or a peer-reviewed review advises against it. Ask your doctor first: a source says to limit it or to check with a doctor, the sources we read disagree, or we found too little to go on. Generally considered OK: every source we read that covers it says it can be used. No stamp replaces your OB-GYN.
Three stamps. The cautious one wins.
Avoid while pregnant: an FDA label, the AAD, ACOG or a peer-reviewed review advises against it. Ask your doctor first: a source says to limit it or to check with a doctor, the sources we read disagree, or we found too little to go on. Generally considered OK: every source we read that covers it says it can be used. No stamp replaces your OB-GYN.
Everything in this tool, in full
Tap the actives you use or paste a label. Each one gets a stamp and the reason, from the AAD, ACOG, FDA labels and MotherToBaby. Not medical advice: bring it to your OB-GYN.
- Avoid while pregnant
- Ask your doctor first
- Generally considered OK
Checking a whole product? The skincare ingredient checker adds pore grades, fragrance allergens and active clashes to the same list. Checking a whole routine? The routine checker stamps every step and pauses what to avoid.
What the sources agree on
Three stamps. The cautious one wins.
Avoid while pregnant: an FDA label, the AAD, ACOG or a peer-reviewed review advises against it. Ask your doctor first: a source says to limit it or to check with a doctor, the sources we read disagree, or we found too little to go on. Generally considered OK: every source we read that covers it says it can be used. No stamp replaces your OB-GYN.
The one group everyone avoids
The AAD, ACOG and MotherToBaby all advise avoiding retinoids during pregnancy, from prescription tretinoin and tazarotene to adapalene and retinol you can buy off the shelf. Taken by mouth, retinoids are known to cause birth defects. On the skin, only a small amount is absorbed, and MotherToBaby says studies haven’t found more birth defects with proper use of tretinoin. They’re avoided to be safe, and because other options exist.
AAD: pregnancy skin careACOGMotherToBaby: acne productsMotherToBaby: tretinoin2026 review (news summary)
Don’t panic. Tell your OB-GYN.
Stop the retinoid and tell your OB-GYN or dermatologist. For tretinoin on the skin, MotherToBaby says studies haven’t found a greater chance of birth defects with proper use. Isotretinoin pills are different: the AAD says to stop them immediately, so contact your prescriber now. MotherToBaby specialists answer questions: call 866-626-6847 or text 855-999-3525.
MotherToBaby: tretinoinAAD: acne in pregnancyMotherToBaby: acne products
Keep the sunscreen
Pregnancy can bring melasma: brown patches on the cheeks, nose and forehead. ACOG advises sunscreen and a wide-brimmed hat every day you’re outside. The AAD suggests a broad-spectrum, water-resistant SPF 30 or higher, and a mineral one (zinc oxide, titanium dioxide) during pregnancy.
Spot creams can wait
Hydroquinone is on the AAD’s avoid list for pregnancy. ACOG says melasma often fades after delivery, though some patches can last for years. A 2023 American Family Physician review lists tretinoin and hydroquinone as options after delivery, and MotherSafe advises against hydroquinone while breastfeeding.
Breastfeeding is a different question
Most sources on this page are about pregnancy. What they say about breastfeeding: MotherToBaby says most over-the-counter acne treatments haven’t been well studied, the amount in milk is likely low, and not to put them on the nipple or areola. MotherSafe says most skin care is generally considered safe while breastfeeding, except hydroquinone. The Differin label says to ask a doctor, the tretinoin label advises caution, and the Tazorac label says there’s no data. Ask your OB-GYN or your baby’s doctor.
MotherToBaby: acne productsMotherSafeDifferin labelTretinoin labelTazorac label
Every ingredient, sourced
26 skincare ingredients and medicines: 11 to avoid while pregnant, 11 to ask your doctor about first, 4 generally considered OK. When sources disagree, the row says who says what.
| Ingredient | Stamp | Why, and who says so |
|---|---|---|
| Retinoids | ||
Retinol & other retinoidsRetinol, retinal, retinyl palmitate: over the counter |
Avoid while pregnant | The AAD says retinoids should not be used during pregnancy, and lists over-the-counter retinol among the ingredients to avoid. ACOG also advises avoiding topical retinoids and reading labels, because some over-the-counter products contain them. Sources split. MotherSafe (Royal Hospital for Women, Sydney) says the small amounts of vitamin A in cosmetics are acceptable. We show the more cautious AAD and ACOG advice. Breastfeeding: Cleveland Clinic says providers believe the risk to breastfed babies from topical retinoids is low, since little is absorbed. Keep it off your breasts and ask your provider. AAD: retinoidsAAD: pregnancy skin careACOGCleveland Clinic: retinolMotherSafe |
AdapaleneDifferin Gel 0.1%, over the counter |
Avoid while pregnant | A retinoid you can buy without a prescription. The AAD says most experts recommend stopping it during pregnancy. Its Drug Facts label says to ask a doctor before use if you’re pregnant, and to stop and ask a doctor if you become pregnant. Breastfeeding: Its Drug Facts label says to ask a doctor before use if you’re breast-feeding. AAD: acne in pregnancyAAD: pregnancy skin careDifferin labelMotherToBaby: acne products |
TretinoinRetin-A and generics, prescription |
Avoid while pregnant | The AAD says most experts recommend stopping it during pregnancy. Its FDA label says to use it in pregnancy only if the potential benefit justifies the potential risk to the fetus. MotherToBaby says studies haven’t found more birth defects with proper use on the skin, but that the safest approach may be to avoid it. Breastfeeding: MotherToBaby says it hasn’t been studied in breastfeeding, but so little reaches your body that the amount in milk would probably be small. Its label advises caution. AAD: acne in pregnancyTretinoin labelMotherToBaby: tretinoinChien 2016 |
TazaroteneTazorac, prescription |
Avoid while pregnant | Its FDA label says it is contraindicated in pregnancy, because retinoids may cause fetal harm, and asks for a negative pregnancy test within 2 weeks before starting. The AAD lists it with the acne medicines never to take during pregnancy. Breastfeeding: Its label says there is no information on tazarotene in breast milk. A 2026 review, as summarized in Dermatology Times, says it’s avoided while breastfeeding too. Tazorac labelAAD: acne in pregnancyChien 20162026 review (news summary) |
| Acne | ||
Salicylic acid, 2% or lessCleansers, toners, spot gels (BHA) |
Ask your doctor first | The AAD says it’s generally considered safe when used for a limited time, and to talk with your OB-GYN or dermatologist before using it. ACOG lists over-the-counter salicylic acid among the acne products that can be used. A 2016 review says the risk is low if use is limited to small areas for a short time. US over-the-counter acne products contain 0.5% to 2% salicylic acid (FDA acne monograph). Breastfeeding: MotherToBaby says most over-the-counter acne treatments haven’t been well studied in breastfeeding, that the amount in milk is likely low, and not to apply them to the nipple or areola. AAD: acne in pregnancyACOGChien 2016Cutis 2024FDA acne monograph |
Salicylic acid peel or above 2%In-office peels, strong at-home peels |
Avoid while pregnant | The AAD lists salicylic acid at high doses (greater than 2%) among the ingredients to use sparingly in pregnancy and to discuss with your dermatologist. For peels, InfantRisk Center says salicylic acid itself appears safe, but that because peels mix ingredients at unknown strengths, it’s best to postpone chemical peels until after delivery. A 2026 review, as summarized in Dermatology Times, says salicylic acid peels are avoided during pregnancy, especially at higher strengths. AAD: pregnancy skin careInfantRisk2026 review (news summary) |
Benzoyl peroxideAcne washes, gels and creams |
Ask your doctor first | The AAD says experts consider it safe in limited amounts, and to check with your OB-GYN or dermatologist before using it. ACOG lists it among the over-the-counter acne products that can be used, and reviews in 2016 and 2024 call it safe in pregnancy. Breastfeeding: A 2026 review, as summarized in Dermatology Times, calls it acceptable while breastfeeding. MotherToBaby says not to apply acne treatments to the nipple or areola. AAD: acne in pregnancyAAD: pregnancy skin careACOGChien 2016Cutis 20242026 review (news summary)MotherToBaby: acne products |
Azelaic acidFinacea, Azelex, 10% serums |
Generally considered OK | The AAD says it’s thought to be safe to use during pregnancy, and animal studies haven’t shown birth defects. ACOG lists it among the over-the-counter products that can be used, and a 2023 American Family Physician review calls it a preferred, safe option. The Azelex prescription label says to use it during pregnancy only if clearly needed. Breastfeeding: Its label says less than 4% is absorbed, so it isn’t expected to change azelaic acid levels in breast milk much. A 2026 review, as summarized in Dermatology Times, calls it acceptable while breastfeeding. AAD: acne in pregnancyACOGAAFP 2023Chien 2016Cutis 2024Azelex label2026 review (news summary) |
Clindamycin gelPrescription acne antibiotic |
Ask your doctor first | The AAD says applying it during pregnancy is thought to be safe, but to check with your obstetrician or dermatologist first. A 2016 review calls short-term use safe and says chronic use hasn’t been studied. AAD: acne in pregnancyChien 2016AAFP 2023 |
| Glow, spots & hydration | ||
Glycolic or lactic acidAHA toners, serums, at-home peels |
Ask your doctor first | ACOG lists over-the-counter glycolic acid among the products that can be used, and a dermatologist in the AAD’s pregnancy guide suggests it at night. But InfantRisk Center says it’s best to avoid glycolic acid until more research is done, and a 2026 review, as summarized in Dermatology Times, says low-strength glycolic or lactic acid may be used with caution. Sources split. We show the cautious stamp. Your OB-GYN can tell you which advice fits you. ACOGAAD: pregnancy skin careInfantRisk2026 review (news summary)Chien 2016MotherSafe |
Vitamin CAscorbic acid and its forms |
Generally considered OK | MotherToBaby lists vitamin C products among those with fewer concerns in most cases, and a 2026 review, as summarized in Dermatology Times, calls vitamin C acceptable during pregnancy and breastfeeding. A dermatologist in the AAD’s pregnancy guide suggests it in the morning. Breastfeeding: The same review summary calls it acceptable while breastfeeding. MotherToBaby: skin care2026 review (news summary)AAD: pregnancy skin care |
NiacinamideVitamin B3, in serums and moisturizers |
Ask your doctor first | A form of vitamin B3. The only source we found on niacinamide in pregnancy is a news summary, in Dermatology Times, of a 2026 review: it says niacinamide is considered acceptable during pregnancy and breastfeeding. We found no study of niacinamide on skin in pregnancy, and the AAD, MotherToBaby, InfantRisk and MotherSafe pages we read don’t mention it. With this little to go on, we show the cautious stamp: ask your OB-GYN. Breastfeeding: The same review summary calls it acceptable while breastfeeding. 2026 review (news summary)Cleveland Clinic: niacinamideAAD: pregnancy skin careMotherToBaby: skin careInfantRiskMotherSafe |
Hyaluronic acidSodium hyaluronate, in hydrating serums |
Generally considered OK | Cleveland Clinic says reactions are rare and that it’s safe to use if you’re pregnant or nursing. The AAD and ACOG pages don’t mention it. Breastfeeding: Cleveland Clinic says it’s safe to use if you’re nursing. Cleveland Clinic: hyaluronic acid |
HydroquinoneDark-spot and melasma creams |
Avoid while pregnant | The AAD lists it among the ingredients to avoid during pregnancy. A large share gets into the body: InfantRisk Center puts it at 30 to 40 percent after use on the skin. Breastfeeding: MotherSafe says to avoid it while breastfeeding too, because absorption is high. AAD: pregnancy skin careInfantRiskMotherSafe2026 review (news summary) |
| Sunscreen | ||
Mineral sunscreenZinc oxide, titanium dioxide |
Generally considered OK | The AAD suggests a physical sunscreen with zinc oxide, titanium dioxide or both during pregnancy, to avoid irritation. MotherToBaby says these minerals aren’t absorbed through the skin, and that a lotion is a better pick than a spray. The FDA proposes both as safe and effective. Breastfeeding: MotherSafe says sunscreens don’t pose a risk to breastfeeding women. AAD: pregnancy skin careMotherToBaby: sunscreenFDA: sunscreenMotherSafe |
Chemical sunscreen filtersAvobenzone, oxybenzone, octinoxate, homosalate… |
Ask your doctor first | The FDA says 12 of these filters need more data before it can call them safe and effective, and that this is not a finding that they’re unsafe. It encourages anyone worried about using sunscreen while pregnant to ask their health care professional. MotherToBaby says they aren’t known to harm a pregnancy but haven’t been studied well. Don’t skip sunscreen: the AAD’s pick for pregnancy is a mineral one. Sources split. MotherSafe says sunscreens don’t pose a risk in pregnancy. We show the more cautious stamp. Breastfeeding: MotherSafe says sunscreens don’t pose a risk to breastfeeding women. FDA: sunscreenMotherToBaby: sunscreenMotherToBaby: skin careAAD: pregnancy skin careMotherSafe |
| Also flagged in ingredient lists | ||
ParabensMethyl-, ethyl-, propyl-, butylparaben |
Ask your doctor first | The AAD lists these four parabens among the ingredients to use sparingly in pregnancy, because some are safe only in limited amounts or haven’t been studied enough. The FDA says it has no information showing that parabens as used in cosmetics affect human health. AAD: pregnancy skin careFDA: parabens |
PhthalatesDiethyl, dibutyl, dimethyl phthalate |
Ask your doctor first | The AAD lists them among the ingredients to use sparingly in pregnancy. The FDA says it has no evidence that phthalates as used in cosmetics pose a safety risk, and that diethyl phthalate is the only one still commonly used. AAD: pregnancy skin careFDA: phthalates |
Some essential oilsRosemary, basil, jasmine, sage |
Ask your doctor first | The AAD names rosemary, basil, jasmine and sage essential oils among the ingredients to use sparingly in pregnancy and to discuss with your dermatologist. AAD: pregnancy skin care |
TriclosanAntibacterial ingredient |
Ask your doctor first | The AAD lists triclosan among the ingredients to use sparingly in pregnancy and to discuss with your dermatologist. AAD: pregnancy skin care |
PhenolAlso used in deep chemical peels |
Ask your doctor first | The AAD lists phenol among the ingredients to use sparingly in pregnancy and to discuss with your dermatologist. Deep phenol peels are another matter: a 2026 review, as summarized in Dermatology Times, says to avoid them during pregnancy and breastfeeding. Breastfeeding: The same review summary says to avoid deep phenol peels while breastfeeding. AAD: pregnancy skin care2026 review (news summary) |
| Other prescription medicines | ||
IsotretinoinAccutane, Absorica: acne pills |
Avoid while pregnant | The AAD lists it among the acne medicines never to take during pregnancy, because it can cause serious birth defects: if you’re pregnant, stop it immediately. ACOG says it should not be used during pregnancy. AAD: acne in pregnancyACOG |
SpironolactonePills for acne or hair loss |
Avoid while pregnant | The AAD lists it with isotretinoin and tazarotene as acne medicines that can cause serious birth defects: if you’re pregnant, stop it immediately. AAD: acne in pregnancyAAD: pregnancy skin care |
Tetracycline antibioticsDoxycycline, minocycline, tetracycline: antibiotic pills used for acne |
Avoid while pregnant | The AAD lists tetracycline, doxycycline and minocycline, types of antibiotics, among the ingredients that can put your baby at risk of birth defects and should not be used during pregnancy. Its page on acne in pregnancy says to stop taking them by your 15th week of pregnancy. InfantRisk Center says oral tetracyclines are contraindicated during pregnancy because they may hold back bone growth. AAD: pregnancy skin careAAD: acne in pregnancyInfantRisk |
FinasteridePills for hair loss |
Avoid while pregnant | The AAD lists finasteride, which treats hair loss, among the ingredients that can put your baby at risk of birth defects and should not be used during pregnancy. AAD: pregnancy skin care |
5-FluorouracilPrescription cream for skin cancer |
Avoid while pregnant | The AAD lists 5-fluorouracil, a chemotherapy cream used to treat skin cancer, among the ingredients that can put your baby at risk of birth defects and should not be used during pregnancy. AAD: pregnancy skin care |
Building a routine from the bottom shelf?
Vitamin C, hyaluronic acid and azelaic acid got the “Generally considered OK” stamp. Before you layer two, see how they get along. Breaking out after a new product? Try the purging checker or the pore checker.
One face scan. Your whole routine, sorted.
This page answered your question. MySkincare starts from your own skin, and the products you already use.
- 1Scan your face3 photos: front, left profile, right profile.
- 2See your skin scoreFree6 zones scored separately: forehead, eye area, T-zone, both cheeks, chin.
- 3Scan your productsIt reads each ingredient list and says: keep it, watch it or replace it.
- 4Follow your routineMorning and night, checked so your products work together. With reminders.
Questions people ask
Is azelaic acid safe during pregnancy?
It’s generally considered OK. The AAD says azelaic acid is thought to be safe to use during pregnancy, and animal studies haven’t shown birth defects. ACOG lists it among the over-the-counter acne products that can be used. The Azelex prescription label says to use it during pregnancy only if clearly needed, so tell your OB-GYN you use it.
Is benzoyl peroxide safe during pregnancy?
Ask your doctor first. The AAD says experts consider it safe in limited amounts, and to check with your obstetrician or dermatologist before using it. ACOG lists it among the over-the-counter acne products that can be used.
Is salicylic acid safe during pregnancy?
It depends on the product. For a wash, toner or spot gel (US over-the-counter acne products contain 0.5% to 2%), the AAD says it’s generally considered safe when used for a limited time, after you talk with your doctor. Above 2%, the AAD says to use it sparingly and to discuss it with your dermatologist. For peels, InfantRisk Center says it’s best to postpone chemical peels until after delivery, and a 2026 review, as summarized in Dermatology Times, says salicylic acid peels are avoided during pregnancy.
Is glycolic acid safe during pregnancy?
The sources disagree, so ask your OB-GYN. ACOG lists over-the-counter glycolic acid among the products that can be used, and a dermatologist in the AAD’s pregnancy guide suggests it at night. InfantRisk Center says it’s best to avoid it until more research is done, pointing to animal studies at doses higher than in cosmetics. A 2026 review, as summarized in Dermatology Times, says low-strength glycolic or lactic acid may be used with caution.
Can I use retinol while pregnant?
The AAD says retinoids should not be used during pregnancy, and lists over-the-counter retinol among the ingredients to avoid. That goes for adapalene (Differin), tretinoin and tazarotene too. One Australian service, MotherSafe, considers the small amounts of vitamin A in cosmetics acceptable; we show the more cautious US advice. If you used retinol before you knew, stop and tell your OB-GYN.
Is niacinamide safe during pregnancy?
Ask your OB-GYN first: the evidence is thin. The only source we found is a news summary, in Dermatology Times, of a 2026 review: it says niacinamide is considered acceptable during pregnancy and breastfeeding. We found no study of niacinamide on skin in pregnancy, and the AAD, MotherToBaby, InfantRisk and MotherSafe pages we read don’t mention it, so we show the cautious stamp.
Can I use hyaluronic acid while pregnant?
Cleveland Clinic says hyaluronic acid is safe to use if you’re pregnant or nursing, and that reactions are rare. The AAD and ACOG pages don’t mention it.
Is vitamin C safe during pregnancy?
It’s generally considered OK. MotherToBaby lists vitamin C products among those with fewer concerns in most cases, and a 2026 review, as summarized in Dermatology Times, calls vitamin C acceptable during pregnancy and breastfeeding. A dermatologist in the AAD’s pregnancy guide suggests using it in the morning.
What sunscreen is safe during pregnancy?
The AAD suggests a broad-spectrum, water-resistant sunscreen with SPF 30 or higher, and a physical one with zinc oxide, titanium dioxide or both during pregnancy. MotherToBaby says those minerals aren’t absorbed through the skin, and suggests a lotion rather than a spray. Chemical filters aren’t known to harm a pregnancy, but the FDA says it needs more data on 12 of them and encourages anyone concerned to ask their health care professional.
Is Differin (adapalene) or tretinoin safe while pregnant?
No. The AAD says most experts recommend stopping both during pregnancy, and the Differin Drug Facts label says to ask a doctor before use if you’re pregnant. Tazarotene (Tazorac) is stricter still: its FDA label says it is contraindicated in pregnancy.
What about Accutane, spironolactone or doxycycline?
Isotretinoin (Accutane) and spironolactone: never during pregnancy. The AAD lists them, with tazarotene, as acne medicines that can cause serious birth defects, and says to stop them immediately if you’re pregnant. The AAD’s pregnancy skin care page also lists tetracycline, doxycycline and minocycline (antibiotics), finasteride (for hair loss) and 5-fluorouracil (a skin cancer cream) among the ingredients that should not be used during pregnancy; its acne page says to stop the tetracyclines by your 15th week. InfantRisk Center says oral tetracyclines are contraindicated in pregnancy. If you take one of these, tell your OB-GYN and the doctor who prescribed it.
Are parabens safe during pregnancy?
The AAD lists methyl-, ethyl-, propyl- and butylparaben among the ingredients to use sparingly in pregnancy, because some are safe only in limited amounts or haven’t been studied enough. The FDA says it has no information showing that parabens as used in cosmetics affect human health.
Is it different when breastfeeding?
Yes, it’s a different question, and many sources here cover pregnancy only. MotherToBaby says most over-the-counter acne treatments haven’t been well studied in breastfeeding and that the amount in milk is likely low; don’t apply them to the nipple or areola. MotherSafe says to avoid hydroquinone while breastfeeding. Ask your doctor or your baby’s doctor.
Each ingredient, in detail
A full page per ingredient — what the AAD, ACOG and the labels say, with every source.
- Is retinol safe?
- Is salicylic acid safe?
- Is benzoyl peroxide safe?
- Is azelaic acid safe?
- Is niacinamide safe?
- Is vitamin C safe?
- Is hyaluronic acid safe?
- Is glycolic acid safe?
- Is adapalene safe?
- Is tretinoin safe?
- Is tazarotene safe?
- Is hydroquinone safe?
- Is clindamycin safe?
- Is mineral sunscreen safe?
- Is chemical sunscreen safe?
- Are parabens safe?
- Are phthalates safe?
- Are essential oils safe?
- Is triclosan safe?
- Is phenol safe?
- Is isotretinoin safe?
- Is spironolactone safe?
- Is doxycycline safe?
- Is finasteride safe?
- Is 5-fluorouracil safe?
Sources
- Educational content, not medical advice
- When sources disagree, the row says who says what
US Food and Drug Administrationfda.gov
- Azelex (azelaic acid 20%): FDA label, 2024
Use during pregnancy only if clearly needed; less than 4% is absorbed, so breast milk levels aren’t expected to change much.
- Questions and answers on its regulatory actions on OTC sunscreen (2026)
Zinc oxide and titanium dioxide proposed as safe and effective; 12 other filters need more data, which isn’t a finding that they’re unsafe; people concerned about sunscreen while pregnant should ask their health care professional.
- Parabens in Cosmetics
No information showing that parabens as used in cosmetics affect human health.
- Phthalates in Cosmetics
No evidence that phthalates as used in cosmetics pose a safety risk; diethyl phthalate is the only one still commonly used.
MotherToBabymothertobaby.org
- Topical Acne Treatments (fact sheet, February 2026)
Only a small amount is absorbed; OTC topical acne treatments haven’t been linked to more birth defects; topical retinoids like adapalene are generally avoided; breastfeeding: not well studied, keep off the nipple and areola.
- Topical Tretinoin (fact sheet, July 2024)
Studies haven’t found more birth defects with proper use on the skin; the safest approach may be to avoid it; breastfeeding not studied, amount in milk probably small.
- What’s the Skinny on Skin Care? (2021)
Retinoids, high-dose salicylic acid, hydroquinone and chemical sunscreens have some concerns; vitamin C products have fewer concerns in most cases. No mention of niacinamide.
- Screening Your Sunscreen During Pregnancy (2020)
Chemical filters: some absorption in small amounts, not well studied in pregnancy, not known to harm it. Zinc oxide and titanium dioxide aren’t absorbed; lotion rather than spray.
American Academy of Dermatologyaad.org
- Is any acne treatment safe to use during pregnancy?
Isotretinoin, tazarotene and spironolactone: never take during pregnancy; if you’re pregnant, stop them immediately. Doxycycline, minocycline or tetracycline: stop by your 15th week of pregnancy. Adapalene and tretinoin: most experts recommend stopping. Azelaic acid and clindamycin: thought to be safe. Benzoyl peroxide and salicylic acid: safe in limited amounts or for a limited time, ask first.
- Dermatologist-approved pregnancy skin care (updated June 2025)
Should not be used during pregnancy, because they can put your baby at risk of birth defects: retinoids (including OTC retinol and adapalene), hydroquinone, finasteride, spironolactone, tetracycline, doxycycline and minocycline, and 5-fluorouracil cream. Use sparingly: salicylic acid at high doses (greater than 2%), benzoyl peroxide, parabens, phthalates, phenol, triclosan, some essential oils. Mineral sunscreen, SPF 30+. Vitamin C in the morning, glycolic acid at night. No mention of niacinamide.
- Retinoid or retinol?
“Retinoids” covers vitamin A-based skin products; retinoids should not be used during pregnancy.
DailyMed, US National Library of Medicinedailymed.nlm.nih.gov
- Tazorac (tazarotene) gel: FDA label (DailyMed)
Contraindicated in pregnancy; negative pregnancy test within 2 weeks before starting; no information on breast milk.
- Tretinoin cream: FDA label (DailyMed, revised March 2026)
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus; no adequate studies in pregnant women; caution while nursing.
- Differin Gel (adapalene 0.1%): Drug Facts label (DailyMed)
“If pregnant or breast-feeding, ask a doctor before use”; stop and ask a doctor if you become pregnant or plan to.
Cleveland Clinicclevelandclinic.org
- Retinol
Healthcare providers discourage retinoids during pregnancy; the risk to breastfeeding infants is believed to be low.
- Hyaluronic Acid (2022)
Reactions are rare, and it’s safe to use if you’re pregnant or nursing.
- Niacinamide (2026)
Niacinamide is a type of vitamin B3; it says nothing about pregnancy.
American College of Obstetricians and Gynecologistsacog.org
- Skin Conditions During Pregnancy, patient FAQ
Over-the-counter products with benzoyl peroxide, azelaic acid, salicylic acid or glycolic acid can be used; use of topical retinoids is generally avoided, and some OTC products contain them; isotretinoin should not be used; melasma and daily sunscreen.
Electronic Code of Federal Regulationsecfr.gov
- FDA OTC acne monograph, 21 CFR 333.310
OTC acne products: salicylic acid 0.5 to 2 percent; benzoyl peroxide 2.5 to 10 percent.
InfantRisk Center, Texas Techinfantrisk.com
- An Overview of the Safety of Skin Care Products During Pregnancy (2020)
Topical retinoids and hydroquinone (30 to 40 percent absorbed) should be avoided; best to avoid glycolic acid until more research; salicylic acid, benzoyl peroxide and azelaic acid considered safe; salicylic acid appears safe in peels, but best to postpone chemical peels until after delivery; oral tetracyclines contraindicated in pregnancy (possible inhibition of bone growth). No mention of niacinamide.
Studies and other sources
- Chien et al., Treatment of Acne in Pregnancy, J Am Board Fam Med, 2016jabfm.org
Benzoyl peroxide considered safe; salicylic acid low risk if limited to local areas for a limited time; azelaic acid a baseline option; no reports of harm from glycolic acid; topical retinoids generally avoided, tazarotene contraindicated; short-term topical clindamycin safe.
- Yaghi, Baboun & Keri, Acne and Pregnancy: A Clinical Review and Practice Pearls, Cutis, 2024doi.org
Benzoyl peroxide and 20% azelaic acid safe in pregnancy; salicylic acid likely safe at low concentrations over limited body areas.
- Erlandson, Wertz & Rosenfeld, Common Skin Conditions During Pregnancy, Am Fam Physician, 2023aafp.org
Topical benzoyl peroxide, azelaic acid and antibiotics are preferred and considered safe for acne; tretinoin and hydroquinone are melasma options after delivery; broad-spectrum sunscreen.
- Dermatology Times (September 3, 2026), news summary of Kovacs et al., Cosmetic Dermatology in Pregnancy and Lactation: A Risk-Benefit Framework for Clinical Practice, Int J Dermatol, 2026 (a narrative review; news summary only, the review itself not read)dermatologytimes.com
Vitamin C, azelaic acid, niacinamide and benzoyl peroxide considered acceptable in pregnancy and breastfeeding; low-strength glycolic or lactic acid may be used with caution in pregnancy; salicylic acid peels avoided in pregnancy, particularly at higher strengths; hydroquinone avoided; tazarotene and deep phenol peels avoided in pregnancy and breastfeeding; reproductive safety data are limited.
- MotherSafe, Royal Hospital for Women (Sydney): Skin Care, Hair Care and Cosmetic Treatments in Pregnancy and Breastfeeding (2021)seslhd.health.nsw.gov.au
Cosmetic vitamin A acceptable; tretinoin should not be used; salicylic acid, benzoyl peroxide and glycolic acid considered safe; hydroquinone avoided in pregnancy and breastfeeding; sunscreens pose no risk. No mention of niacinamide.